Named after eminent science fiction writers Isaac Asimov and Arthur C. Subsequent sequels follow Isaac's struggle to cope with the alteration of his mind by the Marker in the first game, as well as his journey to uncover the origin of the Markers and the source of the Necromorph outbreaks. Once on board the derelict vessel, Isaac finds himself beset by Necromorphs, horrendous undead creatures unleashed by a mysterious alien artifact known as a Marker. A starship systems engineer, he is initially contracted by the Concordance Extraction Company (C.E.C) to join the crew of its maintenance ship Kellion on a search and repair mission for USG Ishimura, which is the last known whereabouts of his ex-girlfriend Nicole Brennan who had sent a brief transmission to him.

He was introduced as the protagonist of Dead Space (2008) developed by EA subsidiary EA Redwood Shores, which later became Visceral Games. Isaac Clarke is a fictional character in the survival horror media franchise Dead Space, owned and published by Electronic Arts. Isaac Clarke as depicted in promotional material for Dead Space 2

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